Uric Acid And Multiple Sclerosis. Uric acid a peroxynitrite scavenger inhibits CNS inflammation bloodCNS barrier permeability changes and tissue damage in a mouse model of multiple sclerosis FASEB J 14 2000 pp. A small study of ten patients with progressive MS has demonstrated some improved function in three of them and no sign of progression or relapse in. Low serum uric acid is linked to multiple sclerosis. Several studies indicate that patients with multiple sclerosis MS have low serum levels of the endogenous antioxidant uric acid UA although it has not been established whether UA is primarily deficient or secondarily reduced due to its peroxynitrite scavenging activity.
The study concluded that their findings supported the importance of uric acid as a biomarker for multiple sclerosis and its progression even though previous studies suggest that uric acid may play a limited role as a disease marker and as therapeutic option in MS patients. Reportedly the process of demyelination and axonal injury in MS and NMO disease induces the excessive formation of reactive oxygen ROS and nitrogen species RNS Peng et al 2012. Meta-analysis of 10 case-control studies found that the serum uric acid levels of patients with multiple sclerosis were significantly lower compared to those of healthy controls possibly indicating a diagnostic biomarker for multiple sclerosis. There was a 39 reduction in risk of death for each 1 mgdL increase in uric acid. Recently uric acid the end of purine metabolism is considered to be a scavenger of ROS and RNS Hooper et al 1998. Inosine a uric acid precursor can be used to raise uric acid levels in serum and may provide some benefit in MS patients.
To evaluate the correlation between serum UA levels and several clinical parameters of MS reliably.
Uric acid in relapsing-remitting multiple sclerosis. Low serum uric acid is linked to multiple sclerosis. Uric acid UA is reduced in MS and possibly relates to MS outcomes with lower UA levels in subjects experiencing a relapse. A 2-year longitudinal study. Uric acid in relapsing-remitting multiple sclerosis. Uric acid levels in MS patients are lower than in controls and in patients with active disease lower than in MS patients in remission.