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Idiopathic Pulmonary Fibrosis 2018. Idiopathic pulmonary fibrosis IPF is a progressive fatal cellular senescence-associated disease. However increased levels of lactate were found in IPF lungs suggesting that all products of glycolysis are shuttled toward lactate production. The global idiopathic pulmonary fibrosis treatment market expected to reach US 35 billion by 2021 growing at CAGR 144 over the forecast period. Adult patients with newly detected interstitial lung disease ILD of apparently unknown cause are clinically suspected of having idiopathic pulmonary fibrosis IPF if they have unexplained symptomatic or asymptomatic patterns of bilateral fibrosis on a chest radiograph or chest computed tomography CT scan bibasilar inspiratory crackles and an age typically older than 60 years.
The approval of medical treatments for idiopathic pulmonary fibrosis IPF marks a new era in approaching this deadly disease. However increased levels of lactate were found in IPF lungs suggesting that all products of glycolysis are shuttled toward lactate production. Idiopathic pulmonary fibrosis IPF is a progressive fatal cellular senescence-associated disease. This document provides clinical recommendations for the diagnosis of idiopathic pulmonary fibrosis IPF. Two guidance documents for the diagnosis of idiopathic pulmonary fibrosis IPF have been recently published by international experts representing major respiratory and radiological societies 1 2. This is clearly a positive sign of the increasing attention being paid by the scientific community to a group of fibrotic lung diseases of which IPF is the prototype.
Two new documents on the diagnosis of IPF have been published in 2018.
Idiopathic pulmonary fibrosis IPF the most common form of fibrosing idiopathic interstitial pneumonia is an inexorably progressive disease with a 5-year survival of 20. It requires early recognition and intervention with supportive care and pharmacologic agents to. Idiopathic pulmonary fibrosis IPF is a chronic and progressive fibrosing interstitial pneumonia of uncertain origin associated with a poor prognosis 1. Idiopathic Pulmonary Fibrosis diagnosis Idiopathic Pulmonary Fibrosis drug therapy Idiopathic Pulmonary Fibrosis physiopathology. Idiopathic pulmonary fibrosis IPF prognosis is heterogeneous despite antifibrotic treatment. This document provides clinical recommendations for the diagnosis of idiopathic pulmonary fibrosis IPF.