19
Apr
Dopamine Theory Of Schizophrenia. Initially the emphasis was on a role of hyperdopaminergia in the etiology of schizophrenia version I but it was subsequently reconceptualized to specify subcortical hyperdopaminergia with prefrontal hypodopaminergia version II. The original dopamine hypothesis stated that schizophrenia suffered from an excessive amount of dopamine. The dopamine hypothesis of schizophrenia simply stated postulates that certain dopaminergic pathways are overactive in schizophrenia and so cause the symptoms of an acute schizophrenic episode. Further evidence implicating the dopamine system in the pathophysiology of schizophrenia has subsequently accumulated and it remains the case that all licensed firstline treatments for schizophrenia operate primarily via antagonism of the dopamine D2 receptor 4.
The dopamine hypothesis of schizophrenia simply stated postulates that certain dopaminergic pathways are overactive in schizophrenia and so cause the symptoms of an acute schizophrenic episode. Further evidence implicating the dopamine system in the pathophysiology of schizophrenia has subsequently accumulated and it remains the case that all licensed firstline treatments for schizophrenia operate primarily via antagonism of the dopamine D2 receptor 4. Schizophrenics according to this theory do not respond appropriately to the social environment like their normal counterparts. The original dopamine hypothesis was put forward by Van Rossum in 1967 that stated that there was hyperactivity of dopamine transmission which resulted in symptoms of schizophrenia and drugs that blocked dopamine reduced psychotic symptoms. High dopamine activity leads to acute episodes and positive symptoms which include. They lose touch with reality.
The dopamine hypothesis of schizophrenia simply stated postulates that certain dopaminergic pathways are overactive in schizophrenia and so cause the symptoms of an acute schizophrenic episode.
Clinical studies indicate that drugs like L-dopa or amphetamine which potentiate dopaminergic activity may induce or exacerbate schizophrenic. The original dopamine hypothesis stated that schizophrenia suffered from an excessive amount of dopamine. The dopamine hypothesis of schizophrenia simply stated postulates that certain dopaminergic pathways are overactive in schizophrenia and so cause the symptoms of an acute schizophrenic episode. This hypothesis argues that overproduction or excessive release of dopamine is part of what causes schizophrenia. Dopamine is an important neurotransmitter in the brain that moderates basic behaviors like motivation. This theory argues that the symptoms of schizophrenia are related to the increased level or excessive amount of dopamine neurotransmitter in the brain.