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Acute Toxicity Studies In Rats. In the first acute and subacute toxicity study male Sprague-Dawley rats of 300-350 g were gavaged with 0 20 40 or 80 mg CCl4kg once daily for 5 consecutive. The acute oral LD 50 in male Sprague-Dawley S-D rats was estimated in the present study to be 82 gkg of body weight bw. Warheit DB Brown SC Donner EM. Exceptions are possible if justifiable.
In the sub-acute study female and male rats age 10 weeks were supplemented at doses of 250 500 and 1000mgkg for 28 days. This investigation was conducted to characterize the acute subacute and subchronic toxic potency of ingested carbon tetrachloride CCl4. In subacute toxicity study CULHA was administered once a day at three dose levels of 100 200 and 400 mg. Healthy male and female Wistar albino rats aged between 10 to 12 weeks and weighing 190 to 210 g adult were selected. Repeated Dose Toxicity Studies Study design Rodents. Food and chemical toxicology 2015 v84 pp.
According to Finneys probit analysis method at 48 h LD 50 value of cypermethrin in rats was found to be 205 mgkg bw by gavage.
Exceptions are possible if justifiable. 8-10 per dose per sex 3 dosages Other approaches. Healthy male and female Wistar albino rats aged between 10 to 12 weeks and weighing 190 to 210 g adult were selected. In the sub-acute study female and male rats age 10 weeks were supplemented at doses of 250 500 and 1000mgkg for 28 days. In acute toxicity the dosage was 2000 mgkg body weight for four female rats. The total gingerols content in the purified viscous extract was 36-43.